CASE FILES: BIOCHEMISTRY
A. Hexokinase is found in most tissues, and because of the very low
Km for glucose, it is designed to work maximally to provide ATP for
tissue even at low levels of glucose. Hexokinase is inhibited by glucose
6-phosphate and is most active with low levels of glucose 6-phosphate.
Glucokinase found in the liver has a high Km for glucose and is very
active after a meal. The glucose in the soda would likely be used for
B IO C H E M IS T R Y PE A R L S
The etiology of the syndrome is not clear, although recent reports
have linked some cases of AFLP with a fetal inborn error in fatty
Following a meal, glycogen concentrations within the liver rise rap-
idly to high levels; this can be up to 10 percent of the wet weight
of the liver.
Liver insufficiency may be associated with hypoglycemia.
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