484
INDEX
Posttranscription modification,
tRNA, 85
PPARs (peroxisome proliferator-
activated receptors), 296
Pregnancy
acute fatty liver in, 179-185
cholestasis of, 303-306
folic acid deficiency in, 36
ovarian cycle and, 431-433, 432/
Pregnenolone, 445, 446/
Premutation, 126
Previtamin D3, 313, 315/
Primary bile acids, 285, 304
Primary protein structure, 11-12
Primase, 105
Proenzymes, 173
Progesterone, 431, 445, 446/
Progesterone receptors, 431
Progestogens, 68
Prokaryote, protein synthesis and,
87-88,
87t
Proline, 378t
Promoter region deletions, 115
Promoter sequence, 113
Proopiomelanocortin, 437
Prophase, 28-29
Propionyl CoA, 388, 388/
Propylthiouracil (PTU), 66
Prostacyclin, 296
Prostacyclin synthase, 296
Prostaglandin(s), 295-299
Prostaglandin H synthase (PGHS), 294,
296-297, 298
/
Prostanoids, 295-297, 297
/
Protease inhibitors, 50
Protein(s)
denaturation, 57, 58, 59/
growth hormone and, 425
negative nitrogen balance and,
357-361
structure, 11-12
synthesis, 85-89,
86/,
357
Protein-energy malnutrition, 328.
See also
Starvation
Protein kinase A, 199
carbohydrate metabolism and,
183, 184/
glucagon and, 203,
203/,
238
in ovarian cycle, 431
Protein kinase C, 70, 457
Protein phosphatase 1, 185, 201-202,
202
/,
203
/,
235
Proteoglycans, 265, 267
Proton gradient, 191-192
Protooncogene, 104
Protoporphyrin IX, 401, 403/
Protoporphyrinogen III, 403/
Protoporphyrinogen oxidase (PPO),
401, 403
PRPP (5-phosphoribosyl-1-
pyrophosphate), 395
Pruritus, in cholestasis of pregnancy,
303-304, 306
Pseudo-Cushing syndrome, 445, 449
PTH (parathyroid hormone), 455-458
PTU (propylthiouracil), 66
Puberty, 431, 432/
Purine(s), 26, 27
t,
360, 393
Purine base ring system, 31, 31/
Purine nucleoside analogs, 20, 21
Purine salvage pathway, 393-395, 394/
Puromycin, 88
Pyelonephritis, 132
Pyridoxal phosphate, 357, 358, 401, 402
Pyrimidine, 27t, 360
Pyrophosphate, 343
Pyruvate, 135, 136/
in glycolytic pathway, 246
/,
250
/
in malignant hyperthermia, 166
metabolic fate, 213, 214t
metabolism, 210-214
rhabdomyolysis and, 192
Pyruvate carboxylase, 192, 193/
Pyruvate dehydrogenase, 136,
142-143, 142/
Pyruvate kinase, 135,
193/,
202
/,
203
/,
204
deficiency, 209-216
in glycolytic pathway, 246
/,
250
/
6-Pyruvoyl-tetrahydropterin, 348
Q
Quaternary protein structure, 11-12
Quinolone antibiotics, 94, 95,
95/,
97/
R
Radioactive iodine, 72
Raffinose, 231
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