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CASE FILES: BIOCHEMISTRY
Figure 32-2. Steps in conversion of arachidonic acid (AA) to PGH2 by PGH
synthase. A cosubstrate, indicated by e-, is required to furnish two reducing
equivalents for the peroxidase reaction.
coon
.coon
Aspirin
(S)-Flurbiprofen
C
,COO
Inuomct m an
(CHj),CH
- - 0 - C
COOH
Ibuprofen
Rofecoxib
Ce ecoxib
Figure 32-3. Structures of some cyclooxygenase inhibitors.
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