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CASE FILES: BIOCHEMISTRY
COOH
(-NHR)
c o o h
(-NHR)
Cholesterol
Cholesterol 7a-hydroxylase
(CYP7A1)
mixed-function oxidases
reduction of A5
I
c
I
I
\ c
COOH
COOH
-NHR)
<■
-NHR)
primary
Cholic acid
Chenodeoxycholic acid
secondary
Deoxycholic acid
Lithocholic acid
Reactions occuring in the liver:
COOH
(N H R )
Reactions occuring in the
excreted
intestine by bacterial action:
Figure 31-1. Simplified biosynthetic pathway of bile salts.
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