CLINICAL CASES
239
Figure 26-4. Schematic diagram showing how epinephrine leads to the break-
down of glycogen, the synthesis of glucose and export of glucose to the blood-
stream. Epinephrine binds to both a- and P-adrenergic receptors on the plasma
membrane of hepatocytes, leading to increased release of Ca2+ and activation
of adenylate cyclase and protein kinase A.
C O M P R E H E N SIO N Q U E ST IO N S
A 27-year-old man has been rushed to the emergency room following his sud-
den collapse and entry into a state of unconsciousness. Examination of per-
sonal belongings revealed the patient is an insulin-dependent diabetic.
[26.1] A rapid decline in which of the following humoral factors likely trig-
gered the sudden collapse of the patient?
A. Insulin
B. Glucagon
C. Fatty acids
D. Glucose
E. Triglyceride
[26.2] Which of the following is
least likely
to contribute to the hyper-
glycemia associated with uncontrolled type I diabetes?
A. Decreased skeletal muscle glucose uptake
B. Decreased adipose lipogenesis
C. Increased adipose lipolysis
D. Increased hepatic gluconeogenesis
E. Increased skeletal muscle glycogenolysis
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