CLINICAL CASES
2 3
Glycogen Phosphorylase
GLYCOGENESIS
Slycogen Synthase
G lycogen
Blood
UDP
(n residue¬ę)
UDP G lucose
Glucose
UTP
Glycogen
Glucose 1-P
G lucose 6-P
J fo
(n+1 re s id u e s
G lycolysis
G lycogen
Energy
n residues)
GLYCOGENOLYSIS
Figure 26-2. The biochemical pathways of the synthesis of glycogen (glyco-
genesis) and its breakdown to glucose 6-phosphate (glycogenolysis).
acetyl-CoA is shunted into the pathway of ketone body synthesis (ketogenesis),
allowing continued P-oxidation of fatty acids and therefore maintenance of
high rates of gluconeogenesis. The interplay between glycolysis, gluconeogen-
esis, P-oxidation, and ketogenesis is illustrated in Figure 26-3.
Figure 26-3. Schematic diagram of the interplay of fatty acid breakdown and
ketone body formation with the synthesis (gluconeogenesis) and degradation
of glucose (glycolysis). The P-oxidation of fatty acids provides the energy that
drives the formation of glucose.
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