CLINICAL CASES
207
B IO C H E M IS T R Y PE A R L S
Serum glucose levels are tightly controlled: Insulin promotes glu-
cose utilization and represses endogenous glucose production,
whereas glucagon represses glucose utilization and promotes
endogenous glucose production.
Several types of glucose transport proteins appear on specific tissues
affecting the movement of glucose across cell membranes.
Glucose is converted into glycogen, the storage form of glucose in
mammals, in a process regulated by insulin and insulin-mediated
activation of protein phosphatase 1 (PP1).
REFERENCES
Cohen P. Dissection of the protein phosphorylation cascades involved in insulin and
growth factor action. Biochem Soc Trans 1993;21:555.
Gould GW, Holman GD. The glucose transporter family: structure, function and
tissue-specific expression. Biochem J 1993;295:329.
Newsholme EA, Leech AR. Biochemistry for the Medical Sciences. New York:
Wiley, 1983.
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