CLINICAL CASES
127
[13.2 to 13.3] Use the genetic code for Questions [13.2] and [13.3].
T
C
A
G
Phe
Ser
Tyr
Cys
T
T
Phe
Ser
Tyr
Cys
C
Leu
Ser
STOP
STOP
A
Leu
Ser
STOP
Trp
G
Leu
Pro
His
Arg
T
C
Leu
Pro
His
Arg
C
Leu
Pro
Gln
Arg
A
Leu
Pro
Gln
Arg
G
Ile
Thr
Asn
Ser
T
A
Ile
Thr
Asn
Ser
C
Ile
Thr
Lys
Arg
A
Met
Thr
Lys
Arg
G
Val
Ala
Asp
Gly
T
G
Val
Ala
Asp
Gly
C
Val
Ala
Glu
Gly
A
Val
Ala
Glu
Gly
G
Using the genetic code above, predict the type of mutation that had to
occur to show these alterations in the final protein product for
Questions [13.2] and [13.3]:
[13.2]
Phe
Thr
Val
Tyr
Leu
Gly
Met
TTT
ACA
GTT
TAT
CTC GGG ATG
Phe
Thr
Val
STOP
A. Missense mutation
B. Nonsense mutation
C. Silent mutation
D. Repeat expansion
[13.3]
Phe
Thr
Val
Tyr
Leu
Gly
Met
TTT
ACC
GTT
TAT
CTA GGG ATG
Phe
Thr
Phe
Ile
STOP
A. Deletion of G in third codon
B. Deletion of A in second codon
C. Insertion of T between second and third codons
D. Insertion of GT between AC and A of second codon
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