CASE 10
A 20-year-old female presents to the ER with complaints of fever, pelvic pain,
and some nausea and vomiting increasing over the last 2 days. She denies diar-
rhea or sick contacts. She is currently sexually active with a new partner. On
examination she has a temperature of 38.9°C (102°F) and appears ill. She has
moderate bilateral lower abdominal tenderness and minimal guarding without
rebound or distention. Bowel sounds are present and normal. Pelvic exam
revealed a foul-smelling discharge through cervix with severe cervical motion
tenderness and bilateral adnexal tenderness. Cervical cultures were obtained.
Patient was begun on a quinolone antibiotic.
What is the most likely diagnosis?
What is the biochemical mechanism of action of the quinolone?
What is the role of deoxyribonucleic acid (DNA) topoisomerases?
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