CLINICAL CASES
89
Figure 9-2. Chemical structure of erythromycin.
to the peptidyl or donor site. Erythromycin, which does not reach the peptidyl
transferase center, induces dissociation of peptidyl tRNAs containing six, seven,
or eight amino acid residues.
C O M P R E H E N SIO N Q U E ST IO N S
For each of the following steps in prokaryotic protein synthesis (Questions [9.1]
to [9.3]), indicate the most appropriate antibiotic (A-J) to inhibit the process.
A. Aminoglycosides
B. Chloramphenicol
C. Erythromycin
D. Gentamicin
E. Kanamycin
F. Lincosamides
G. Neomycin
H. Puromycin
I. Streptomycin
J. Tetracycline
[9.1]
Transfer of the peptide from the peptidyl tRNA to the aminoacyl-tRNA
and formation of a peptide bond.
[9.2]
Binding of aminoacyl-tRNA in the A-site of the ribosomal complex.
[9.3]
Translocation of the peptidyl tRNA from the A-site to the P-site.
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